ANTIBODY-SERVICES Antibodies are becoming more and more important for the future drug market with an increasing number of clinical applications. You are looking for outsourcing opportunities to make your research efforts in this field more effective? Take advantage of GLYCOTOPE’s know-how which we offer in a broad range of services in state-of-the-art technologies to reach your next step faster. Our broad experiences allow us to find customized solutions. Are you curious about our know-how? Look at our examples below! Antibody engineering Do you have an already carefully selected and well characterized non-human antibody and want to develop a therapeutic antibody? Do you fear to lose your unique antibody due to unstable hybridoma? Do you need your antibody in a special format? We offer costumized antibody engineering including techniques of antibody sequence cloning, chimerization, humanization and generation of antibody fragments or constructs as e.g. multibodies.

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Expression, Production and Purification You want expression clones or your antibody purified ? We express and develop a purification process for your recombinant antibody in a format of your choice using bacteria or mammalian cell lines. We adapt mammalian cells to serum free conditions. For expressing antibodies with fully human glycosylation and optimized sialylation for high activity and favorable pharmacokinetics please have a look at GlycoExpress.

Biochemical and Functional Characterization You want to know more about your antibody? We analyse its biochemical, immunological and functional properties. Have a look at our examples for the analysis of antibody specificity, affinity and stability as well as functionality like ADCC, phagocytosis and internalization.

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Preclinical Evaluation using Radiolabelled Antibodies You want to learn more about relevant biopharmaceutical properties of your antibody? We evaluate them in vitro as well as in vivo using radionuclides for detection. Well established assays are available for analysis of biochemical and functional properties e.g. stability, affinity, number of binding sites and receptor mediated internalization. Together with our partner EPO-GmbH we offer investigation of pharmacokinetic, biodistribution and therapeutic potential in mice or rats. Numerous animal models are available, especially in the field of cancer.

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Company Contact GLYCOTOPE GmbH Robert-Rössle-Str. 10 13125 Berlin Germany Hans Baumeister, Ph.D. Chief Operating Officer

Telephone:   Fax: E-mail:

+49-30-941084-207 +49-30-9489-2612 hans.baumeister@glycotope.com