Dendritic Cells: DC-Tools

GLYCOTOPE distributes DC-Tools, the dendritic cell products generated from the human dendritic cell line NemodDC.

Product background

NemodDC was generated by NEMOD Biotherapeutics GmbH & Co. KG and represents the worldwide first fully functional human dendritic cell line that can be differentiated into immature DC (i-NMDC) and further matured to mature DC (m-NMDC) with all the phenotypic and functional characteristics typical of human dendritic cells.
(for scientific background)

NemodDC has been developed for the immunotherapy of diseases such as cancer (Dendritic Cells: NemodDC) and also as a tool for research and validation,
called DC-Tools.

Download DC-Tools Flyer (PDF)

Download DC-Tools Order Sheet (PDF)

Download Laborwelt article (PDF in german)


What are DC-Tools?
Fully-functional human dendritic cells (DC)
  i-NMDC      Vials of non-dividing immature DC -
can be further differentiated to
mature DC
  m-NMDC

 Vials of non-dividing mature DC

Human T-cells screened for use with NemodDC available as:
  PBMC
  CD8+ T-cells		   NemodDC
in a mature state
(m-NMDC)

Human T-cells
  CD4+ T-cells
  


What can they be used for?
Vaccines and immunotherapeutics development
  Immunomonitoring
  T cell priming & restimulation
  Antigen processing & epitope characterization
  Evaluation of antigen immunogenicity
  DC functional studies
Pharmaceuticals, foodstuffs and cosmetics development
Investigation of immunostimulatory or immunosuppressive effects
(eg on maturation) of –
  Foodstuffs and ingredients (eg bacteria, food additives, trace contaminants)
  Cosmetics and their ingredients (eg allergy-inducing substances)
  Novel pharmaceuticals and biologicals


What are the advantages?
  Store, thaw and use
  Standardized quality controlled cells
  No time-consuming DC preparation
  No donor blood required
  PBMC/T-cells HLA-matched to NemodDC (HLA-A2)
  T-cells functionally tested for use with NemodDC


What do they cost?

Order No. Product Contents Price (EURO) Description
NMD-100 i-NMDC immature dendritic cells (iDC) 299 5x106 iDC, differentiated
from NemodDC cell line
NMD-200 m-NMDC mature dendritic cells (mDC) 349 2x106 mDC, differentiated
and matured from NemodDC cell line
NMD-300 PBMC-iKit 1 Vial iDC +
1 Vial PBMC		 449 5x106 i-NMDC +
4x107 PBMC
NMD-500 CD8T-iKit 1 Vial iDC +
1 Vial CD8 +
T-cells		 899 5x106 i-NMDC +
2x107 CD8 + T-cells
NMD-600 PBMC-mKit 1 Vial mDC +
1 Vial PBMC		 499 2x106 m-NMDC +
4x107 PBMC
NMD-800 CD8T-mKit 1 Vial mDC +
1 Vial CD8 +
T-cells		 949 2x106 m-NMDC +
2x107 CD8 + T-cells
NMD-900 PBMC 1 Vial PBMC 229 4x107 PBMC matched in
HLA-type & function with NemodDC
NMD-1000 CD4 + T-cells 1 Vial CD4 +
T-cells		 649 2x107 CD4 + T-cells
isolated from PBMC
NMD-1100 CD8 + T-cells 1 Vial CD8 +
T-cells		 649 2x107 CD8 + T-cells
isolated from PBMC
(NMD-900)
ACS-100 cell culture medium 50 ml ready-made 50 ground medium + fcs + conditioned medium
ACS-200 control peptide 20 µg (1 µg/µl) 10 HLA-A2 Nonapeptide from
MART-1 protein used for QC of NMD-100 &
NMD-200
Control peptides and thawing-medium available upon request

                      *****Prizes exclude VAT and delivery costs*****
                      *****CD4+ T cells are prepared on request*****
                          *****effective from January, 1st 2007*****

Note:   The names NemodDC and NMDC (in scientific publications)
refer to the same cell line.


Ordering

DC-Tools products can be ordered through Marcel Kuehnert
Telephone: 
Fax:		 +49-30-941084-242
+49-30-941084-188


Technical questions

For any technical questions, please contact Anja Löffler
Telephone: 
Fax:		 +49-30-941084-311
+49-30-941084-188