Antibodies


GLYCOTOPE distributes the following NEMOD* antibodies, either as cell culture supernatants, purified or labeled:

  Antibodies to core-1 (Thomsen-Friedenreich antigen, CD176)
Details
  Antibodies to blood group H type 2 (CD173)/
  Lewis Y (CD174) antigens
Details
  Antibodies to peptide tumour markers Details
  Antibodies to glycophorin A (CD235a) Details
  Antibodies to cytokeratins Details
  Antibodies to cell cycle-dependent antigens Details
  Antibodies to serum albumins Details
  Antibodies to glycodelin A and conductin
Details


For requests, please contact Hans Baumeister

* the hybridomas are owned by NEMOD Biotherapeutics GmbH & Co. KG


Download List of mouse monoclonal antibodies (PDF)

Download Pricelist of Antibodies (PDF)


More details about the antibodies:

Antibodies to core-1 (Thomsen-Friedenreich antigen, TF, CD176)

Unique panel of antibodies towards TF, a highly specific tumour antigen
Nemod-TF1 M, Gal1-3GalNAc-(Nemod-TF1) (TF >> TF) Capable to bind single TFs, not cross-reactive with Core-2
A78-G/A7 M, Gal1-3GalNAc-(TF > TF), prognostic factor in colorectal and gastric carcinomas, HLDA7 approved
Nemod-TF2 M, Gal1-3GalNAc-(TF > TF) comparable to A78-G/A7, but cross-reacting in ELISA with GlcNAc1-6[Gal1-3]GalNAc-, Core-2), cluster of 2 TFs at a distance of about 13 aa
A63-C/A9 M, TF on glycophorin (mixed epitope in the extracellular domain, aa 34-55)
A68-B/A11 M, Gal1-3GalNAc-(TF >>TF)
A68-E/E3 G1, Gal1-3GalNAc1-(TF)
A68-E/A2 G1, Gal1-3GalNAc1-(TF)

Antibodies to blood group H type 2 (CD173)/ Lewis Y (CD174) antigens

H type 2 and Lewis Y are developmentally regulated antigens
CD173 (H type 2) A46-B/B10 M, Fuca1-2Gal1-4GlcNAc1.
Partially cross-reacting with Lewis Y.
HLDA7 approved
CD173 (H type 2) A63-D/B12 M, Similar to A46-B/B10
CD173 (H type 2) A51-B/A6 A, Fuca1-2Gal1-4GlcNAc1, High affinity
CD174 (LewisY) A70-C/C8 M, Fuca1-2Gal1-4(Fuca1-3)GlcNAc1.
Highly specific, not cross-reacting with
H type 2; HLDA7 approved
CD174 (LewisY) A70-A/A9 G1, Cross-reacting with H type 2 and Leb
Globo-H A69-A/E8 M Fuca1-2Gal1-3GalNAc- (H type 3/4)

Antibodies to peptide tumour markers

Potent and approved antibodies to well established serum tumour markers
AFP
(alpha-fetoprotein)
A34-B/B5 G2a Epitope "a” (AFP). ISOBM TD-2 approved (cluster B)
AFP
(alpha-fetoprotein)
A34-B/B11 G2a Epitope "a”
AFP
(alpha-fetoprotein)
A34-A/B4 G1 Epitope "b”
AFP
(alpha-fetoprotein)
A34-A/D12 G1 Epitope "c”. ISOBM TD-2 approved
(cluster B)
CEA (carcinoembryonic antigen, CD66e) A42-B/A2 G2b Peptide epitope; cross-reacts with NCA antigen
PSA
(prostate-specific antigen)
A67-B/E3 G1 ISOBM TD-3 approved (cluster 5a)

Antibodies to glycophorin A (CD235a)

Exceptional series of antibodies to defined epitopes   1)
A83-C/B12 G1, extracellular domain aGP>GP   2)
A88-A/F9 G2b, extracellular domain aGP>>GP
A88-D/C7 G2b, extracellular domain aGP>>GP
A88-E/H2 G2b, extracellular domain aGP>>GP
A63-B/C2 M, extracellular domain aGP>GP
A63-C/A9 M extracellular domain (+TF) aGP only
A88-E/D1 G1, cytoplasmic domain aGP>GP
A88-E/D6 G1, cytoplasmic domain aGP>GP

1) Inquire for epitope sequences
2) GP = glycophorin, aGP = asiologlycophorin

Antibodies to cytokeratins

Superb antibodies from the original source
Cytokeratin 19 (human) A53-B/A2
G2a, (Ks 19.1)
Specific for certain subtypes of epithelial cells; detects carcinoma cells in non-epithelial tissues (e.g. lymph nodes); differentiation marker in liver development. Epitope: aa 311-335.
Part of the serum tumour marker test CYFRA 21-1; ISOBM TD-5 approved
Cytokeratins
(broad range)
A51-B/H4 G2a Detects CK18 and other cytokeratins, epithal marker. Cross-reacts with lamin

Antibodies to cell cycle-dependent antigens

Novel well suited cell cycle antibodies
A69-D/H7 M, Detects mitotic cells in tissues or cell cultures.
Phosphorylated epitope, antigen different from Ki-67
A73-B/D12 M, NuMA-related antigen

Antibodies to serum albumins

Valuable tools for analytical purposes
Serum albumin
(bovine)
(BSA)
G1, A23-A/D3 High affinity, well suited for the detection of traces of BSA in tissue culture products or other preparations.
Not cross-reacting with HSA.
Serum albumin
(human)
(HSA)
G1 A21-F8 Not cross-reacting with BSA.

Antibodies to glycodelin A (GdA, pp14)

Novel antibodies to an important pregnancy protein
A87-D/C5 G1,G2b,M, Major pregnancy protein with immunosuppressive activity; marker of ovarian carcinomas
A87-D/F4 G1, CH epitope of GdA
A87-B/D2 G1, CH epitope of GdA

Antibody to conductin (axin2, axil)

Unique antibody to a regulator protein of an important signaling pathway (wnt)
A92-C/G7 G1, Conductin is upregulated in colon and liver cancer