Utilizing the company’s unique technology platform, Glycotope has developed a mature pipeline of first-in-class and best-in-class biopharmaceuticals.  Three oncology products are currently in advanced clinical development.

Pipeline Products
Oncology pipeline status

With the combined advantages of optimized sialylation, galactosylation, fucosylation, branching and absence of non-human sugar structures, GEX® products may result in higher efficacy, fewer side effects and/or broader coverage of patients and indications.

Non-oncology pipeline status

With the combined advantages of optimized sialylation, galactosylation, fucosylation, branching and absence of non-human sugar structures, GEX® products may result in higher efficacy, fewer side effects and/or broader coverage of patients and indications.

Partnership Opportunities

Glycotope is currently seeking development and commercialization partners for several of its late-stage assets.

Oncology:

PankoMab-GEX® – Glycotope’s first-in-class antibody against the tumor-specific carbohydrate-protein epitope TA-MUC1 that showed a good safety profile and anti-tumor activity in a single agent Phase 1 study. The compound is currently in a Phase 2 study as maintenance therapy for recurrent ovarian cancer.

CetuGEX® – a novel glyco-optimized anti-epidermal growth factor receptor (EGFR) monoclonal antibody (mAb) that showed promising therapeutic activity in a single agent Phase 1 dose escalation study in patients with various solid tumors. The compound is currently in a Phase 2b study in squamous cell carcinomas of the head and neck.

TrasGEX® – a novel glyco-optimized anti-Her2 receptor mAb that has been tested in a Phase 1/2a clinical trials with in patients with Her-2 positive tumors whose disease progressed following treatment with standard therapies.

Non-oncology:

FSH-GEX® – the first fully human glycosylated FSH (follicle-stimulating hormone) that has successfully completed a Phase II study.