Immunomonitoring

The development of vaccines and immunotherapies requires the sophisticated assessment of immune responses in human clinical trials. Cell-mediated immunity is a key biomarker for most vaccines and immunotherapies and involves the activity of specialised cells including macrophages, dendritic cells, natural killer cells (NK), antigen-specific cytotoxic T lymphocytes, helper T lymphocytes and the release of various cytokines in response to an antigen stimulation.

Immunogenicity Testing, PK and PD Assessment

Drug serum levels
Cytokine release
Anti-drug-antibodies
Screening / confirmation / neutralizing antibodies
Antigen serum levels
Drug’s mode-of-action
Immune cell function

Available Technologies

ELISA in all formats
Electrochemilumiscence (MSD)
Flow cytometry
Surface Plasmon Resonance (Biacore)
ELISpot
Cytotoxicity & Cellular Immunoassays with > 100 cell lines and primary cell preparations

Our Core Competencies

Project consultancy
Assay establishment
Assay validation
Sample measurement
Immunomonitoring of clinical trials